Plone 4.2.5 use more then 110% cpu then hang

usually high CPU means your site is processing more requests it can handle because, a) poor caching configuration at any level (ZODB, plone.app.caching, fontend caching…), b) unoptimized code, or c) everything is fine and you just need more backends.

please do your homework first and come back with more hard information; another must read thread: