Dexterity edit forms attach info to the ObjectModifiedEvent about which field(s) was modified. You can write a handler like this:
def handle_modified(object, event):
if hasattr(event, 'descriptions') and event.descriptions:
for d in event.descriptions:
if d.interface is IMySchema and 'my_field' in d.attributes:
# do things here
Unfortunately there isn't a way to get the old field value from the event handler, though.