Longest run without restarting

[rileydog (Wayne Glover)]

there is a long discussion on the need (or not) of restarting. you might find it interresting

Is auto stop/restart of site still needed to prevent memory build up

[C]Python's memory management does not use compaction. Any long running application with heavy non-formalized heap usage (such a Plone) without memory compaction tends to suffer from memory fragmentation and correspondingly increased memory usage. Things might have improved but likely you still will not be able to run your Plone processes for years.